RESUMO
AIM: To study the expression of the programmed cell death receptor (PD-1) and its ligand (PD-L1) by immunocompetent cells in endometrial cancer patients with metabolic disorders. MATERIALS AND METHODS: Populations and subpopulations of lymphocytes were analyzed by flow cytometry. Antibodies against CD279 were used to detect PD-1 on the CD4+ and CD8+ T cells. Antibodies against CD14 and CD274 were used to detect PD-L1 on monocytes. RESULTS: In patients with severe metabolic disorders, the expression of PD-1 on CD8+ and CD4+ lymphocytes and the expression of the corresponding PD-L1 on CD14+ cells before treatment and after radiation therapy were higher than in the control group. CONCLUSION: Theincreased expression of PD-1 and PD-L1 receptors by immunocompetent cells can be considered a new prognostic marker in endometrial cancer patients with morbid obesity.
Assuntos
Neoplasias do Endométrio , Doenças Metabólicas , Feminino , Humanos , Antígeno B7-H1/metabolismo , Receptor de Morte Celular Programada 1/metabolismo , Neoplasias do Endométrio/complicações , Apoptose , Linfócitos T CD8-Positivos/metabolismoRESUMO
We have analysed the available worlds scientific literature concerning chronotherapy of malignant neoplasms of different localization. The review is focused on the results of multicenter investigations into this problem organized by the chronotherapy group in the framework of EORTC that have demonstrated a higher antiblastoma activity and improved tolerability of preparations applied in the chronomodulated regimen in comparison with the traditional treatment. Our original observations and recommendations ensuing from our many-year experience with the use of chemo- and radiotherapy of rectal and cervical cancer in the optimal time of day for the normal tissues constitute a basis for the more extensive introduction of chronobiological techniques to clinical practice.
Assuntos
Neoplasias/tratamento farmacológico , Neoplasias/radioterapia , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Quimiorradioterapia/métodos , HumanosAssuntos
Ritmo Circadiano , Cronofarmacoterapia , Neoplasias/tratamento farmacológico , Neoplasias/radioterapia , Animais , Neoplasias da Mama/tratamento farmacológico , Neoplasias da Mama/radioterapia , Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico , Carcinoma Pulmonar de Células não Pequenas/radioterapia , Quimioterapia Adjuvante/métodos , Neoplasias Colorretais/tratamento farmacológico , Neoplasias Colorretais/radioterapia , Feminino , Neoplasias dos Genitais Femininos/tratamento farmacológico , Neoplasias dos Genitais Femininos/radioterapia , Neoplasias dos Genitais Masculinos/tratamento farmacológico , Neoplasias dos Genitais Masculinos/radioterapia , Humanos , Neoplasias Pulmonares/tratamento farmacológico , Neoplasias Pulmonares/radioterapia , Masculino , Radioterapia Adjuvante/métodosRESUMO
The time course study of the immunity status of 57 subjects who were engaged in liquidation of consequences of the catastrophe at Chernobyl NPS in May-December, 1986, has revealed a high frequency of disorders in bactericidal and digestive activities of neutrophils, as well as in the functional activity of T-lymphocytes in the peripheral blood. The incidence rate of subjects with disturbed functional activity of T-lymphocytes is significantly higher in the group of subjects with suppressed capacity of blood lymphocytes for DNA repair as compared to those with normal levels of blood lymphocyte capacity for DNA repair.
